Research Opportunity Number: LSI-02
Project Title: Modeling disease dysregulation using large genomic datasets
Project Summary: A key challenge in biomedical science is to understand how the genome, common to all cells in the body, codes for different cell types with broadly diverse functions that change through development, aging and disease. The Troyanskaya lab uses statistical and machine learning approaches to tackle modeling of genome function and mutation impacts, as well as developing genome-wide models for how genes work together in biological processes and pathways in different cell contexts. Summer students will work with a mentor to develop and apply approaches to understand the molecular underpinnings of cell-type diversity and the impact of genetic variants in specific tissue, cell-type, and disease contexts.
Student Roles and Responsibilities: Show up on time, be courteous and respectful of all lab members, ask questions - always!, Come to lab wanting to learn and not afraid to ask questions, and in turn, share information with lab mates. Students are expected to make good faith efforts at their projects. No prior experience is necessary, but an open inquisitive mind is a must.
Additional Considerations: Start and end dates are flexible, but the student should be available essentially full-time (at least 30 hours/week) for 5-6 weeks.
Department/Institute: Lewis-Sigler Institute for Integrative Genomics
Faculty Sponsor: Olga Troyanskaya
Participation Dates: June 27- August 5, 2022
Stipend Offered: $0
Number of Internships Available: 0-4
Application Deadline: March 15, 2022, midnight eastern daylight time