• Princeton-led studies boost CRISPR gene-editing prospects

    Wednesday, Oct 20, 2021
    by Caitlin Sedwick for the Princeton University Department of Molecular Biology

    The ability to edit the genome by altering the DNA sequence inside a living cell is powerful for research and holds enormous promise for the treatment of diseases. However, existing genome editing technologies frequently result in unwanted mutations or can fail to introduce any changes at all. These problems have kept the field from reaching its full potential.

  • Researchers invent world's smallest biomechanical linkage

    Wednesday, Aug 25, 2021
    by Scott Lyon, School of Engineering and Applied Science

    Researchers at Princeton University have built the world's smallest mechanically interlocked biological structure, a deceptively simple two-ring chain made from tiny strands of amino acids called peptides.

  • Princeton-led technology for room-temperature vaccines and biological drugs selected as finalist in Science Center QED research accelerator program

    Wednesday, Jul 28, 2021
    by Catherine Zandonella, Office of the Dean for Research

    A method that enables the storage and transport of vaccines and life-saving drugs at room temperature, eliminating the need for expensive refrigeration or freezing, is one of 12 technologies selected for development through the Philadelphia-based University City Science Center. The Science Center’s QED Proof of Concept program connects university researchers with experts to transform life-sciences discoveries into products and services that benefit human health.

  • Forward Fest public conversation series continues as part of A Year of Forward Thinking

    Tuesday, Mar 16, 2021
    by Princeton University

    Princeton’s Forward Fest — a virtual public conversation series and a monthly highlight of the University’s yearlong A Year of Forward Thinking community engagement campaign — was held on Thursday, March 18, at 3:30 p.m., with a focus on Princeton’s growing interdisciplinary power in bioengineering.

    Watch the conversation on the University's YouTube channel.

  • Forecasting the next COVID-19

    Monday, Dec 14, 2020
    by Jerimiah Oetting, for the Office of the Dean for Research

    Princeton disease ecologist C. Jessica Metcalf and Harvard physician and epidemiologist Michael Mina say that predicting disease could become as commonplace as predicting the weather. The Global Immunological Observatory, like a weather center forecasting a tornado or hurricane, would alert the world, earlier than ever before, to dangerous emerging pathogens like SARS-CoV-2.

  • What caused the ice ages? Tiny ocean fossils offer key evidence

    Thursday, Dec 10, 2020
    by Liz Fuller-Wright, Office of Communications

    The last million years of Earth history have been characterized by frequent “glacial-interglacial cycles,” large swings in climate that are linked to the growing and shrinking of massive, continent-spanning ice sheets. These cycles are triggered by subtle oscillations in Earth’s orbit and rotation, but the orbital oscillations are too subtle to explain the large changes in climate.

  • Computing empowers immune cells to kill cancer

    Monday, Nov 30, 2020
    by Steven Schultz, School of Engineering and Applied Science

    One of the most promising new cancer therapies involves engineering cells from the body's own immune system to attack tumors, but tuning those attackers to spare healthy tissues has been challenging. Now a collaboration of computer scientists and bioengineers has produced a way to select targets with the same kind of logic that drives computers, promising treatments that are both safer and more broadly effective.

  • New technique could help repair nerve damage

    Tuesday, Oct 27, 2020
    by Catherine Zandonella, Office of the Dean for Research

    A new recipe for patterning cells on a surface holds promise for the repair of damaged nerve tissue.

  • Princeton and Mpala scholars link obesity and disease to dramatic dietary changes

    Wednesday, Oct 21, 2020
    by Liz Fuller-Wright, Office of Communications

    Are obesity, diabetes, cardiovascular illnesses and more the result of a “mismatch” between the meals we eat and the foods our bodies are prepared for?

    The “mismatch hypothesis” argues that each of our bodies has evolved and adapted to digest the foods that our ancestors ate, and that human bodies will struggle and largely fail to metabolize a radically new set of foods.


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