Biotechnology

  • Forecasting the next COVID-19

    Monday, Dec 14, 2020
    by Jerimiah Oetting, for the Office of the Dean for Research

    Princeton disease ecologist C. Jessica Metcalf and Harvard physician and epidemiologist Michael Mina say that predicting disease could become as commonplace as predicting the weather. The Global Immunological Observatory, like a weather center forecasting a tornado or hurricane, would alert the world, earlier than ever before, to dangerous emerging pathogens like SARS-CoV-2.

  • What caused the ice ages? Tiny ocean fossils offer key evidence

    Thursday, Dec 10, 2020
    by Liz Fuller-Wright, Office of Communications

    The last million years of Earth history have been characterized by frequent “glacial-interglacial cycles,” large swings in climate that are linked to the growing and shrinking of massive, continent-spanning ice sheets. These cycles are triggered by subtle oscillations in Earth’s orbit and rotation, but the orbital oscillations are too subtle to explain the large changes in climate.

  • Computing empowers immune cells to kill cancer

    Monday, Nov 30, 2020
    by Steven Schultz, School of Engineering and Applied Science

    One of the most promising new cancer therapies involves engineering cells from the body's own immune system to attack tumors, but tuning those attackers to spare healthy tissues has been challenging. Now a collaboration of computer scientists and bioengineers has produced a way to select targets with the same kind of logic that drives computers, promising treatments that are both safer and more broadly effective.

  • New technique could help repair nerve damage

    Tuesday, Oct 27, 2020
    by Catherine Zandonella, Office of the Dean for Research

    A new recipe for patterning cells on a surface holds promise for the repair of damaged nerve tissue.

  • Princeton and Mpala scholars link obesity and disease to dramatic dietary changes

    Wednesday, Oct 21, 2020
    by Liz Fuller-Wright, Office of Communications

    Are obesity, diabetes, cardiovascular illnesses and more the result of a “mismatch” between the meals we eat and the foods our bodies are prepared for?

    The “mismatch hypothesis” argues that each of our bodies has evolved and adapted to digest the foods that our ancestors ate, and that human bodies will struggle and largely fail to metabolize a radically new set of foods.

  • Novel drug could be a powerful weapon in the fight against malaria and toxoplasmosis

    Tuesday, Sep 15, 2020
    by Adam Hadhazy for the Office of Engineering Communications

    Princeton researchers are making key contributions toward developing a promising new treatment for the widespread and devastating diseases toxoplasmosis and malaria.

    The Princeton scientists specialize in preparing the drug compound into a medicine that is both safe and effective for humans and able to reach its intended sites of action in the body in sufficient doses.

  • New tools catch and release cellular targets at the flip of a light switch

    Tuesday, Aug 18, 2020
    by Molly Sharlach, Office of Engineering Communications

    A Princeton team has developed a class of light-switchable, highly adaptable molecular tools with new capabilities to control cellular activities. The antibody-like proteins, called OptoBinders, allow researchers to rapidly control processes inside and outside of cells by directing their localization, with potential applications including protein purification, the improved production of biofuels, and new types of targeted cancer therapies.

  • Study investigates potential for gut microbiome to alter drug safety and efficacy

    Wednesday, Jun 10, 2020
    by Catherine Zandonella, Office of the Dean for Research

    Researchers at Princeton University have developed a systematic approach for evaluating how the microbial community in our intestines can chemically transform, or metabolize, oral medications in ways that impact their safety and efficacy. The new methodology provides a more complete picture of how gut bacteria metabolize drugs, and could aid the development of medications that are more effective, have fewer side effects, and are personalized to an individual’s microbiome.

Pages

Subscribe to Biotechnology