Biotechnology

Brangwynne wins the Breakthrough Prize for revolutionary view of living cells
Sept. 22, 2022
Author
Written by Scott Lyon, Office of Engineering Communications

Princeton bioengineer Clifford Brangwynne has won the 2023 Breakthrough Prize for Life Sciences, recognizing his contributions to the study of living cells.

Brangwynne’s research has…

More possible entry points for COVID spike protein identified by Princeton scientists
Sept. 21, 2022
Author
Written by Wendy Plump, Department of Chemistry

One of the essential factors the COVID-19 virus needs to enter a host is a receptor on a human cell — a place where the universally recognized spike protein can latch onto the cell surface, pierce it, disgorge its infectious contents, and replicate.

Without a receptor, there is no replication. Without replication, there is no infection…

BioLEC2 launches with new round of DOE funding
Aug. 25, 2022
Author
Written by Wendy Plump, Department of Chemistry

The Department of Energy has awarded another four years of funding to the Energy Frontier Research Center helmed by Princeton University’s Department of Chemistry: Bio-Inspired Light-Escalated Chemistry (BioLEC). 

The $12.6M in funding was announced today by the DOE’s Office of Science, Basic Energy Sciences. …

A fast, accurate, equipment-free diagnostic test for SARS-CoV-2 and its variants
Aug. 16, 2022
Author
Written by Caitlin Sedwick for the Department of Molecular Biology

More than two years into the pandemic, the virus that causes COVID—SARS-CoV-2—continues to spread worldwide. Testing for the virus and its variants can help limit transmission and inform treatment decisions, and is therefore an important pillar of the public health response.

Now, a team of researchers from

Our COVID-19 vaccines would not exist without this unsung Princeton technology
May 2, 2022
Author
Written by Scott Lyon, Office of Engineering Communications

It might not look like much — a plastic box that fits in the hand, with tiny tubes jutting out the top and bottom. Too simple to be cutting edge. Too humble to save so many lives.

But for 20 years, researchers in Robert Prud’homme’s lab have fine-tuned this little box that has revolutionized drug manufacturing, enabling everything…

DataX is funding eight new AI research projects across disciplines
April 4, 2022
Author
Written by Sharon Adarlo, Center for Statistics and Machine Learning

Eight new interdisciplinary research projects have won seed funding from Princeton University’s Schmidt DataX Fund, marking the third round of grants undertaken by the fund since 2019. The fund, supported…

New Princeton spinout will bring 'poisoned arrow' antibiotic and other new medicines to the market
March 22, 2022
Author
Written by Wright Señeres, Princeton Entrepreneurship Council; Liz Fuller-Wright, Office of Communications

Two years ago, molecular biologist Zemer Gitai and his research group announced that they had discovered an antibiotic that simultaneously pierced through a disease's defenses while poisoning it from within, like a poison-tipped arrow. And better yet, it was not susceptible to antibiotic resistance.

Discovering the “poisoned arrow"…

Princeton chemists find the surprisingly simple way mammals keep their bloodstream in balance
March 1, 2022
Author
Written by Wendy Plump, Department of Chemistry

Chemists tend to think of the human body as operating out of a sense-and-respond paradigm. For example, you eat sugar, the pancreas senses the intake, and it responds by releasing the hormone insulin to keep your glucose levels in check.

Scientists have long wondered whether there is a similar regulatory strategy for clearing other…

Study uncovers new features of genome organization
Feb. 7, 2022
Author
Written by Caitlin Sedwick for the Department of Molecular Biology

During animal development, specific genes become active in different cells at exact times in order to produce all the tissues and structures of the body. This exquisite genetic choreography is made possible by multiple layers of organization built into organisms’ DNA.  

Now, new research from the laboratory of Princeton scientist

Princeton-led studies boost CRISPR gene-editing prospects
Oct. 20, 2021
Author
Written by Caitlin Sedwick for the Princeton University Department of Molecular Biology

The ability to edit the genome by altering the DNA sequence inside a living cell is powerful for research and holds enormous promise for the treatment of diseases. However, existing genome editing technologies frequently result in unwanted mutations or can fail to introduce any changes at all. These problems have kept the field from reaching…