Our COVID-19 vaccines would not exist without this unsung Princeton technology
May 2, 2022
Written by Scott Lyon, Office of Engineering Communications

It might not look like much — a plastic box that fits in the hand, with tiny tubes jutting out the top and bottom. Too simple to be cutting edge. Too humble to save so many lives.

But for 20 years, researchers in Robert Prud’homme’s lab have fine-tuned this little box that has revolutionized drug manufacturing, enabling everything…

DataX is funding eight new AI research projects across disciplines
April 4, 2022
Written by Sharon Adarlo, Center for Statistics and Machine Learning

Eight new interdisciplinary research projects have won seed funding from Princeton University’s Schmidt DataX Fund, marking the third round of grants undertaken by the fund since 2019. The fund, supported…

New Princeton spinout will bring 'poisoned arrow' antibiotic and other new medicines to the market
March 22, 2022
Written by Wright Señeres, Princeton Entrepreneurship Council; Liz Fuller-Wright, Office of Communications

Two years ago, molecular biologist Zemer Gitai and his research group announced that they had discovered an antibiotic that simultaneously pierced through a disease's defenses while poisoning it from within, like a poison-tipped arrow. And better yet, it was not susceptible to antibiotic resistance.

Discovering the “poisoned arrow"…

Princeton chemists find the surprisingly simple way mammals keep their bloodstream in balance
March 1, 2022
Written by Wendy Plump, Department of Chemistry

Chemists tend to think of the human body as operating out of a sense-and-respond paradigm. For example, you eat sugar, the pancreas senses the intake, and it responds by releasing the hormone insulin to keep your glucose levels in check.

Scientists have long wondered whether there is a similar regulatory strategy for clearing other…

Study uncovers new features of genome organization
Feb. 7, 2022
Written by Caitlin Sedwick for the Department of Molecular Biology

During animal development, specific genes become active in different cells at exact times in order to produce all the tissues and structures of the body. This exquisite genetic choreography is made possible by multiple layers of organization built into organisms’ DNA.  

Now, new research from the laboratory of Princeton scientist

Princeton-led studies boost CRISPR gene-editing prospects
Oct. 20, 2021
Written by Caitlin Sedwick for the Princeton University Department of Molecular Biology

The ability to edit the genome by altering the DNA sequence inside a living cell is powerful for research and holds enormous promise for the treatment of diseases. However, existing genome editing technologies frequently result in unwanted mutations or can fail to introduce any changes at all. These problems have kept the field from reaching…

Researchers invent world's smallest biomechanical linkage
Aug. 25, 2021
Written by Scott Lyon, School of Engineering and Applied Science

Researchers at Princeton University have built the world's smallest mechanically interlocked biological structure, a deceptively simple two-ring chain made from tiny strands of amino acids called peptides.

In a paper published August 23 in Nature…

Princeton-led technology for room-temperature vaccines and biological drugs selected as finalist in Science Center QED research accelerator program
July 28, 2021
Written by Catherine Zandonella, Office of the Dean for Research

A method that enables the storage and transport of vaccines and life-saving drugs at room temperature, eliminating the need for expensive refrigeration or freezing, is one of 12 technologies selected for development through the Philadelphia-based University City Science Center. The Science Center’s QED Proof of Concept program connects…

Forward Fest public conversation series continues as part of A Year of Forward Thinking
March 16, 2021
Written by Princeton University

Princeton’s Forward Fest — a virtual public conversation series and a monthly highlight of the University’s yearlong A Year of Forward Thinking community engagement campaign — was held on Thursday, March 18, at 3:30 p.m., with a…

New study provides detailed view of how hepatitis B virus establishes chronic infection
March 11, 2021
Written by Caitlin Sedwick for the Department of Molecular Biology

Researchers at Princeton have determined how five cellular proteins contribute to an essential step in the life cycle of hepatitis B virus (HBV). The article describing these findings appeared March 11, 2021 in the journal Nature Communications.