Biotechnology

Researchers invent world's smallest biomechanical linkage
Aug. 25, 2021
Author
Written by Scott Lyon, School of Engineering and Applied Science

Researchers at Princeton University have built the world's smallest mechanically interlocked biological structure, a deceptively simple two-ring chain made from tiny strands of amino acids called peptides.

In a paper published August 23 in Nature…

Princeton-led technology for room-temperature vaccines and biological drugs selected as finalist in Science Center QED research accelerator program
July 28, 2021
Author
Written by Catherine Zandonella, Office of the Dean for Research

A method that enables the storage and transport of vaccines and life-saving drugs at room temperature, eliminating the need for expensive refrigeration or freezing, is one of 12 technologies selected for development through the Philadelphia-based University City Science Center. The Science Center’s QED Proof of Concept program connects…

Forward Fest public conversation series continues as part of A Year of Forward Thinking
March 16, 2021
Author
Written by Princeton University

Princeton’s Forward Fest — a virtual public conversation series and a monthly highlight of the University’s yearlong A Year of Forward Thinking community engagement campaign — was held on Thursday, March 18, at 3:30 p.m., with a…

New study provides detailed view of how hepatitis B virus establishes chronic infection
March 11, 2021
Author
Written by Caitlin Sedwick for the Department of Molecular Biology

Researchers at Princeton have determined how five cellular proteins contribute to an essential step in the life cycle of hepatitis B virus (HBV). The article describing these findings appeared March 11, 2021 in the journal Nature Communications.

Viruses…

Forecasting the next COVID-19
Dec. 14, 2020
Author
Written by Jerimiah Oetting, for the Office of the Dean for Research

Princeton disease ecologist C. Jessica Metcalf and Harvard physician and epidemiologist Michael Mina say that predicting disease could become as commonplace as predicting the weather. The Global Immunological Observatory, like a weather center forecasting a tornado or hurricane, would…

What caused the ice ages? Tiny ocean fossils offer key evidence
Dec. 10, 2020
Author
Written by Liz Fuller-Wright, Office of Communications

The last million years of Earth history have been characterized by frequent “glacial-interglacial cycles,” large swings in climate that are linked to the growing and shrinking of massive, continent-spanning ice sheets. These cycles are triggered by subtle oscillations in Earth’s orbit and rotation, but the orbital oscillations are too subtle to…

Computing empowers immune cells to kill cancer
Nov. 30, 2020
Author
Written by Steven Schultz, School of Engineering and Applied Science

One of the most promising new cancer therapies involves engineering cells from the body's own immune system to attack tumors, but tuning those attackers to spare healthy tissues has been challenging. Now a collaboration of computer scientists and bioengineers has produced a way to select targets with the same kind of logic that drives computers…

New technique could help repair nerve damage
Oct. 27, 2020
Author
Written by Catherine Zandonella, Office of the Dean for Research

A new recipe for patterning cells on a surface holds promise for the repair of damaged nerve tissue.

Princeton researchers — led by Jeffrey Schwartz, professor of chemistry, and

Princeton and Mpala scholars link obesity and disease to dramatic dietary changes
Oct. 21, 2020
Author
Written by Liz Fuller-Wright, Office of Communications

Are obesity, diabetes, cardiovascular illnesses and more the result of a “mismatch” between the meals we eat and the foods our bodies are prepared for?

The “mismatch hypothesis” argues that each of our bodies has evolved and adapted to digest the foods that our ancestors ate, and that human bodies will struggle and largely fail to…

Largest COVID-19 contact tracing study to date finds children key to spread, evidence of superspreaders
Sept. 30, 2020
Author
Written by Morgan Kelly, Princeton Environmental Institute

A study of more than a half-million people in India who were exposed to the novel coronavirus SARS-CoV-2 suggests that the virus’ continued spread is driven by only a small percentage of those who become infected.

Furthermore, children and young adults were found to be potentially much more important to transmitting the virus —…