MacMillan illuminates the micro-environment, creating a new path to cancer drugs
March 5, 2020
Written by Wendy Plump, Department of Chemistry

When corporate partners in the Princeton Catalysis Initiative sat down two years ago with David MacMillan, they presented him with a biological challenge at the heart of potential cancer medicines and other therapeutics: which proteins on a cell’s surface touch each other?

Geneticists pump the brakes on DNA, revealing key developmental process
March 5, 2020
Written by Scott Lyon, Office of Engineering Communications

Researchers at Princeton University have revealed the inner workings of a gene repression mechanism in fruit fly embryos, adding insight to the study of human diseases.

Led by graduate student Shannon Keenan, the team used light to activate chemical signals in developing fruit flies and traced the effects on a protein…

It’s all in the delivery — nanoparticle platform could transform medical treatments
Feb. 12, 2020
Written by Amelia Herb, Office of Engineering Communications

Optimeos Life Sciences, a startup founded by two Princeton University faculty members, has reached agreements with six pharmaceutical companies to develop therapeutics using a Princeton-developed drug delivery technology. The collaborations have the potential to improve the effectiveness of medications for the treatment of diseases, ranging…

Researchers uncover potential cancer-causing mutations in genes’ control switches
Feb. 5, 2020
Written by Molly Sharlach, Office of Engineering Communications

Using sophisticated algorithms to explore regions of the genome whose roles in cancer have been largely uncharted, an international team of researchers has opened the door to a new understanding of the disease’s genetic origins.

The discovery involves areas of DNA that do not directly code for…

By recreating cell division in a test tube, researchers discover vital role for protein elevated in a quarter of all cancers
Jan. 15, 2020

Researchers at Princeton University have successfully recreated a key cell-division step in a test tube, uncovering the vital role played by a protein that is elevated in over 25% of all cancers. The two studies, which appear today in the journals Nature Communications and eLife, are from the laboratory of Sabine Petry, assistant professor of…

AI-based motion-capture system for animals has applications from drug development to ecology
Jan. 8, 2020
Written by Catherine Zandonella, Office of the Dean for Research

A new system that uses artificial intelligence to track animal movements is poised to aid a wide range of studies, from exploring new drugs that affect behavior to ecological research. The approach, shown in the video above, can be used with laboratory animals such as fruit flies and mice as well as larger animals.

The technology —…

Identifying new drugs to cure hepatitis B and E virus infection
Dec. 31, 2019
Written by Catherine Zandonella, Office of the Dean for Research

A new approach for discovering antivirals against hepatitis B and E viruses aims to identify new drug candidates for these life-threatening diseases.

Building on his lab’s expertise in human liver pathogens, Alexander Ploss, associate professor of…

Climate change could make RSV respiratory infection outbreaks less severe, more common
Dec. 16, 2019
Written by Morgan Kelly, Princeton Environmental Institute

One of the first studies to examine the effect of climate change on diseases such as influenza that are transmitted directly from person to person has found that higher temperatures and increased rainfall could make outbreaks less severe but more common, particularly in North America.

Princeton University-led researchers studied how…

Princeton researchers listen in on the chemical conversation of the human microbiome
Dec. 13, 2019
Written by Caitlin Sedwick for the Department of Molecular Biology

The microbial community populating the human body plays an important role in health and disease, but with few exceptions, how individual microbial species affect health and disease states remains poorly understood. A new study by Princeton researcher

Stone and Sturm named to National Academy of Inventors
Dec. 6, 2019
Written by the Office of Engineering Communications

The National Academy of Inventors has named Princeton engineering professors Howard Stone and James Sturm among 168 fellows for 2019.

Stone is the chair…