Two Princeton professors — one who explores the interior structures of cells, and another who mathematically defines thresholds between shifting, complex systems — have been awarded 2018 MacArthur Fellowships. Choreographer and performer Okwui Okpokwasili, a Hodder Fellow in the Lewis Center for the Arts, also received an award.
- Thursday, Oct 4, 2018
- Tuesday, Sep 25, 2018
Scientists have long prized the roundworm Caenorhabditis elegans as a model for studying the biology of multicellular organisms. The millimeter-long worms are easy to grow in the lab and manipulate genetically, and they have only around 1,000 cells, making them a powerful system for probing intricacies of development, behavior and metabolism.
- Wednesday, Sep 12, 2018
Princeton postdoctoral research associate Melanie McReynolds has been selected by the Howard Hughes Medical Institute (HHMI) as one of 15 Hanna Gray Fellows. The awards, established by HHMI to support diversity in science, are given to exceptional early-career scientists with the potential to become leaders in academic research.
- Tuesday, Sep 4, 2018
- Wednesday, Aug 8, 2018
By analyzing data from thousands of patients, Princeton researchers have identified genetic mutations that frequently occur in people with uterine cancer, colorectal cancer or skin cancer — an important step toward using genome sequences to better understand cancer and guide new treatments.
- Monday, Aug 6, 2018
Bringing new drugs to market takes time. Laboratory testing, clinical research and U.S. Food and Drug Administration review — and all the steps in between — add up to 17 years, on average, for research evidence to reach clinical practice.
But what if organic chemists could speed up that process by providing medicinal chemists with new tools that would facilitate selective molecule activation to support drug discovery?
- Thursday, Jul 26, 2018
In a development with implications for better understanding disease, researchers have created a computational system to predict the effect that mutations in noncoding DNA — sections that don’t produce proteins — have on tissues and cells in the human body.
- Tuesday, Jul 3, 2018
Princeton researchers have developed a new computational method that increases the ability to track the spread of cancer cells from one part of the body to another.
This migration of cells can lead to metastatic disease, which causes about 90 percent of cancer deaths from solid tumors — masses of cells that grow in organs such as the breast, prostate or colon. Understanding the drivers of metastasis could lead to new treatments aimed at blocking the process of cancer spreading through the body.
- Monday, Jul 2, 2018
For bacteria facing a dose of antibiotics, timing might be the key to evading destruction. In a series of experiments, Princeton researchers found that cells that repaired DNA damaged by antibiotics before resuming growth had a much better chance of surviving treatment.
When antibiotics hit a population of bacteria, often a small fraction of “persister” cells survive to pose a threat of recurrent infection. Unlike bacteria with genetic resistance to antibiotics, evidence suggests that persisters stay alive in part by stalling cellular processes targeted by the drugs.
- Thursday, Jun 21, 2018
Princeton chemists have found a way to make a naturally occurring enzyme take on a new, artificial role, which has significant implications for modern chemistry, including pharmaceutical production. Their work appears in the journal Nature Chemistry.