Biotechnology

In the tissues of a tiny worm, a close-up view of where genes are working
Sept. 25, 2018
Author
Written by Molly Sharlach, School of Engineering and Applied Science

Scientists have long prized the roundworm Caenorhabditis elegans as a model for studying the biology of multicellular organisms. The millimeter-long worms are easy to grow in the lab and manipulate genetically, and they have only around 1,000 cells, making them a powerful system for probing intricacies of…

McReynolds wins HHMI Hanna Gray Fellowship for early career researchers
Sept. 12, 2018
Author
Written by Liz Fuller-Wright, Office of Communications

Princeton postdoctoral research associate Melanie McReynolds has been selected by the Howard Hughes Medical Institute (HHMI) as one of 15 Hanna Gray Fellows. The awards, established by HHMI to support…

Bassler receives Schering Prize for discovering bacterial communication
Sept. 4, 2018
Author
Written by Liz Fuller-Wright, Office of Communications

Schering Stiftung announced Monday, Sept. 3, that they were awarding the 2018 Ernst Schering Prize to molecular biologist Bonnie Bassler for her pioneering…

From 'sea of mutations,' two possible cancer links rise to the surface
Aug. 8, 2018
Author
Written by Molly Sharlach, Office of Engineering Communications

By analyzing data from thousands of patients, Princeton researchers have identified genetic mutations that frequently occur in people with uterine cancer, colorectal cancer or skin cancer — an important step toward using genome sequences to better understand cancer and guide new treatments.

MacMillan lab finds new way to bond molecules that could speed drug discovery
Aug. 6, 2018
Author
Written by by Amy Carleton

Bringing new drugs to market takes time. Laboratory testing, clinical research and U.S. Food and Drug Administration review — and all the steps in between — add up to 17 years, on average, for research evidence to reach clinical practice.

But what if organic chemists could speed up that process by providing medicinal chemists with new…

Method reveals how hidden DNA mutations affect tissues
July 26, 2018
Author
Written by Adapted from the Simons Foundation

In a development with implications for better understanding disease, researchers have created a computational system to predict the effect that mutations in noncoding DNA — sections that don’t produce proteins — have on tissues and cells in the human body.

Genes produce proteins that keep your body functioning and healthy. But genes…

Researchers apply computing power to track the spread of cancer
July 3, 2018
Author
Written by Molly Sharlach, Office of Engineering Communications

Princeton researchers have developed a new computational method that increases the ability to track the spread of cancer cells from one part of the body to another.

This migration of cells can lead to metastatic disease, which causes about 90 percent of cancer deaths from solid tumors — masses of cells that grow in organs such as the…

Timing is key for bacteria surviving antibiotics
July 2, 2018
Author
Written by Molly Sharlach, Office of Engineering Communications

For bacteria facing a dose of antibiotics, timing might be the key to evading destruction. In a series of experiments, Princeton researchers found that cells that repaired DNA damaged by antibiotics before resuming growth had a much better chance of surviving treatment.

When antibiotics hit a population of bacteria, often a small…

Princeton chemists teach an enzyme a new trick, with potential for building new molecules  
June 21, 2018
Author
Written by Liz Fuller-Wright, Office of Communications

Princeton chemists have found a way to make a naturally occurring enzyme take on a new, artificial role, which has significant implications for modern chemistry, including pharmaceutical production. Their work appears in the journal Nature Chemistry.

“We have found a…

Modern alchemists are making chemistry greener
June 14, 2018
Author
Written by Liz Fuller-Wright, Office of Communications

Ancient alchemists tried to turn lead and other common metals into gold and platinum. Modern chemists in Paul Chirik’s lab at Princeton are transforming reactions that have depended on environmentally unfriendly precious metals, finding cheaper and greener alternatives to replace platinum,…