• Modern alchemists are making chemistry greener

    Thursday, Jun 14, 2018
    by Liz Fuller-Wright, Office of Communications

    Ancient alchemists tried to turn lead and other common metals into gold and platinum. Modern chemists in Paul Chirik’s lab at Princeton are transforming reactions that have depended on environmentally unfriendly precious metals, finding cheaper and greener alternatives to replace platinum, rhodium and other precious metals in drug production and other reactions.

  • Immune cell provides cradle for mammary stem cells

    Thursday, May 17, 2018
    by Catherine Zandonella, Office of the Dean for Research

    A new study finds that one of the toughest characters in the immune system, the macrophage, has a nurturing side, at least when it comes to guarding the developing breast.

    The study published online this week in the journal Science found that macrophages play an important role in maintaining the mammary gland's stem cell niche, a sort of nursery for the precursors of milk-producing cells in the breast.

  • Petry finds missing ingredient to spark the fireworks of life

    Wednesday, May 16, 2018
    by Liz Fuller-Wright, Office of Communications

    Most people can name at least a few bones of the human body, but not many know about the cytoskeleton within our cells, let alone the “microtubules” that give it its shape. Now, a group of Princeton researchers has resolved a long-standing controversy by identifying exactly how the body creates these micron-sized filaments.

  • Researchers use light to turn yeast into biochemical factories

    Thursday, Mar 22, 2018
    by Lonnie Shekhtman for the Office of Engineering Communications

    Scientists have recently learned how to use light to control specific groups of neurons to better understand the operation of the brain, a development that has transformed areas of neuroscience. Researchers at Princeton University have now applied a similar method to controlling the metabolism, or basic chemical process, of a living cell. In a series of experiments, they used light to control genetically modified yeast and increase its output of commercially valuable chemicals. The results offer scientists a powerful new tool to probe and understand the inner working of cells.

  • Bioinformatics points the way to treating pancreatic cancer

    Friday, Sep 22, 2017
    A new study that sifted through a vast amount of biomolecular data has significantly advanced our understanding of the genetics of pancreatic cancer and opened up promising new treatment avenues. Ben Raphael, a professor of computer science, was a lead researcher in the computational analysis of the dataset of molecular changes in a large sample of malignant pancreatic tumors from 150 patients.
  • Scientists demonstrate path to linking the genome to healthy tissues and disease

    Monday, Oct 16, 2017
    An international group of researchers, known as the GTEx Consortium, is studying the diversity of genetic roles in maintaining human tissues. Barbara Engelhardt, an assistant professor of computer science, is a lead author on an article by the group published in Nature about how genetic variation affects gene regulation in 44 human tissue types.
  • LEDs light the way for better drug therapies

    Thursday, Nov 9, 2017
    David MacMillan’s lab partnered with Merck to develop a new process for creating radioactive versions of drug molecules, a critical step for tracing where the drugs go and monitoring their impact on the body. Previous attempts to create radioactive labels took months, but Dave’s process can do it in less than a day.


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